New Research Shows Experimental Treatment Working For Advanced Cancer Cases

New Research Shows Experimental Treatment Working For Advanced Cancer Cases

New Research Shows Experimental Treatment Working For Advanced Cancer Cases

The charity Breast Cancer Now said the findings were "practice-changing".

The good news for around 70,000 women each year comes from the largest study done of breast cancer treatment.

One more thing the new findings show? Chemotherapy, which is medication that kills cancer cells, can keep the cancer from spreading but can also affect health cells and cause unwanted side effects, such as hair loss, anxiety, depression, nausea, fatigue and heart failure. There is no published evidence for Keytruda having any effect on HR-positive breast cancer, and the researchers say the short course of the drug is unlikely to have been able to confer such a protracted benefit on its own. They were scored using the Oncotype DX genetic test, which assesses how the cancer is likely to respond to treatment. Your odds of being cured are terrific, and you don't need chemotherapy because you don't need it.

The study used a gene test done on tumors to help decide whether a woman would benefit from chemo or if they could receive hormone therapy. Of those women, 6,711 had test scores between 11 and 25, which placed them in the intermediate risk group. "The trial was created to address this question, and provides a very definitive answer".

Until now, women have faced a great deal of uncertainty about whether to add chemo to hormone therapy after a diagnosis with hormone-receptor positive, HER-2 negative breast cancer when found at an early stage before it has spread to the lymph nodes. All had received a mid-range Oncotype DX score.

It addresses the sensitive issue which is being regularly raised in healthcare today: when is chemotherapy really necessary and when it is not, the underlying question being if the majority of patients is receiving chemotherapy unnecessarily.

A high recurrence score, above 25, means chemo is advised to ward off a recurrence while a low score, below 10, means it is not.

Then, researchers studied the outcomes, including whether or not cancer recurred, and overall survival.

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Patients with a recurrence score of up to 10 out of 100 have previously been shown not to benefit from chemotherapy, and instead need only hormone treatment. "We knew we were overtreating a lot of women with chemotherapy, in our gut". "But we need to be precise on when to use it and who to recommend it to".

More than two years on, she is cancer-free and says she has "gone back to normal everyday life", even enjoying strenuous hiking and kayaking trips.

It is estimated that 3,000 to 5,000 women in the United Kingdom are likely to avoid chemotherapy every year following the trial.

In doing so - they'll avoid the side-effects that come along with it.

"When someone had an intermediate score, it was hard to decide whether or not to proceed with chemotherapy", Bernik said.

Researchers at the National Cancer Institute (NCI) examined over 10,000 breast cancer patients and found that women who were treated with an estrogen-blocking hormone therapy had a almost identical survival rate to women treated with chemo and hormone therapy.

"The results of our trial suggest that the 21-gene assay may identify up to 85% of women with early breast cancer who can be spared adjuvant chemotherapy, especially those who are older than 50 years of age and have a recurrence score of 25 or lower, as well as women 50 years of age or younger with a recurrence score of 15 or lower", the authors conclude.

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